Essay - Sickle Cell Anemia: Annotated Bibliography Preface: the Resources Annotated in...

Sickle Cell Anemia:

***** Bibliography

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The resources annotated in the following bibliography provide a detailed overview of sickle cell anemia, also known simply as sickle ***** disease. Within the bibliography is a general description of ***** d*****ease, including its causes, prevalence, and pathology—the way the disease progresses and the symptoms it causes. Other studies that were included in this bibliography build on this information, describing various ways ***** are being researched or have been developed for treating the disease.

Often w*****h ***** cell anemia, the treatment ***** symptoms is the only thing that is truly effective, and some of the studies included here demonstrate this fact. ***** ***** show the exciting new ways in which the very mechanism ***** the ***** is being combated, often through gene therapies. Sickle ***** anemia is caused by a specific mutation on a *****; scientists *****re currently developing ways both to fix that ***** ***** to insert other genes that produce different types of hemoglobin, some of ***** interact with the sickle-causing ***** in ways that disrupt ***** disease's progression. Several of these methods are also ***** *****in, along with other interesting facts and vital pieces of information regarding sickle cell anemia.

Townes, T., Jeanisch, R. et al. (2007). "Treatment ***** sickle cell anemia mouse model with IPS cells generated from autologous skin." Science, 318:1920-1923. Etreived via Gale Genereal reference Center Gold.

*****: This article details how scientist were able to take ***** ***** the tails of mice and make them behave as though they were embryonic stem cells. These so-called induced pluripotent cells have received much attention because they have ***** the same medical usefulness ***** embryonic stem cells—which exhibit ***** ability ***** become any ***** type of cell in the body, promis*****g to eventually lead to whole new therapeutic techniques ***** ***** to combat dise*****e. Pluripotent cells ***** especially appealing ***** they provide a way around the ethical and moral objections to embryonic ***** cell creation, retrieval, and research, as it requires the destruction ***** an embryo, which is a very nebulous gray area in humans. In this particular study, ***** pluripotent ***** created by the scientists were used to alter DNA in marrow that produced red blood *****s, starting the creation of healthy red blood cells instead of the sickle-shaped ***** ***** are the hallmark of this disease.

Assessment: this ***** is ***** brief, and does not ***** a great deal of details about ***** study. *****stead, ***** focuses on the achievement as another advancement in the use of pluripotent cells, rather than as a step forward in treat*****g sickle cell anemia. The results apply to both are*****, of course, but the article could detail ***** effects of treatment more.

Reflection: Though brief, ***** article was very interesting, and made me realize ***** interconnected the issue ***** ***** cell ***** is ***** other genetic disorders. The focus of the article is on the larger picture, not just the details of this one disease. Still, this means that advancements in treat*****g