Alzheimer's Disease Course Project Part II: Reading Research Paper

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Alzheimer's Disease

Course project part II: Reading and reviewing current epidemiological studies

I selected a variety of studies from international peer-reviewed publications, focusing first on the manifestation of Alzheimer's Disease; the second two on causal factors associated with AD in specific genetic populations.

The first article studied behavioral risk factors, the second genetic risk factors, the third genetic and environmental risk factors.

The determinants of the first study were to examine the phenomenon of the expression of the disease itself, the determinants of the other two were to determine the interplay between various risk factors, including genetic predispositions, heart disease, and educational levels (in the case of the third study).

Study

Satler, Corina; Carlos Uribe, Carlos Conde, Sergio Leme Da-Silva, & Carlos Tomaz. (2010).

Emotion processing for arousal and neutral content in Alzheimer's disease.

International Journal of Alzheimer Disease. Retrieved October 10, 2011 at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915644/

Causality Criteria

Description: An assessment of the ability of Alzheimer's disease (AD) patients to perceive and process emotional information

Exposure, Intervention: Subjects watched a neutral and emotional story, asked to interpret both

Outcome: As well as memory, emotional interpretation was also impacted by AD

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Study design: Experimental; correlative

Study Population: 24 subjects (12 with Alzheimer's Disease, 12 in a control group without AD)

Main Result: Emotional processing is part of the decline associated with AD

Internal Validity

Observation bias: Questionnaires, rather than interviews used to measure validity

Recall bias: Use of Emotional Memory Test, a previously well-tested screening instrument was designed to reduce bias

Research Paper on Alzheimer's Disease Course Project Part II: Reading Assignment

Confounding: Demographic characteristics were assessed by a t-test; emotional rating scores and total answers for each version of the test were evaluated by a mixed-model ANOVA 2 x 2; Stepwise linear regression analyses were performed for each group to determine the best predictors of dependent variables

Chance: Possible, given the small sample size

Generalizability

Eligible population: Patients with AD

Source population: Yes, can be applied to the source AD population

Other population: Other sources of cognitive decline could reduce emotional recall, but that cannot be determined from this study

Study 2:

Chacon, Aldrin E. Molero; Gloria Pino-Ramirez; Jose A. Luchsinger; Joseph H. Lee; & Gladys

E. Maestre. (2010). Risk of dementia associated with elevated plasma homocysteine in a Latin American population. International Journal of Alzheimer Disease. Retrieved October 10, 2011 at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925085/

Causality Criteria

Description: An assessment of the relationship between total homocysteine (tHcy) and dementia risk

Exposure, Intervention: Plasma tHcy, vitamin B12, and folate were measured using blood samples obtained between 7: 00 and 8:00 AM, after overnight fasting to determine plasma levels. Diagnosis of AD was performed according to standard DSM criteria; diagnosis of stroke was self-reported.

Study design: Correlative

Study Population: 2100 Venezuelans (?55 years old) of the Maracaibo Aging Study, designed to study patients with a high genetic risk for developing AD

Main Result: Elevated levels associated with dementia, even when other risk… [END OF PREVIEW] . . . READ MORE

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