Research Paper: Body Surface Area-Based Dosing Flat

Pages: 5 (1439 words)  ·  Bibliography Sources: 5  ·  Level: College Senior  ·  Topic: Medicine  ·  Buy This Paper

SAMPLE EXCERPT:

[. . .] 09 m2

=1.09 m2 / 1.73 m2 = 0.63 X 25 mg = 15.75 mg

It is critical to round off the value to the nearest whole number with the aim of generating an accurate value for the medication. Since 15.75 is closer to the whole number 16 in comparison to 15, it is ideal to round off the value to the nearest 16. This is an indication that the dosage for the scenario is 16 mg q.i.d.

Research where it came from Relatively narrow therapeutic window has been critical in illustrating the concept of Classic cytotoxic. This indicates that 'low' doses of the drugs might prove to be ineffective as well as very toxic in case 'high' doses. It is ideal to note that the optimal dose should be in between thus contributing to the best possible treatment. The overall outcome of the best possible treatment should relate to maximal therapeutic effect in relation to manageable and tolerable toxicities. One of the critical assumptions in relation to dosing is that large patients with larger volume of distribution and greater metabolizing capacity need to be dosed higher in comparison to smaller patients with the aim of achieving adequate and equal drug concentrations. This led to the adoption and integration of the BSA (Body-Surface Area) with the aim of adjusting the traditional administration of doses.

During its initial development stage, BSA was calculated through the length and weight under the influence of DuBois and DuBois in the case of 1916 emanating from the investigation involving nine participants or individuals (DuBois & DuBois, 1916). Despite the lack of validation of the derived formula during the initial stages of its usage, the application of BSA was critical in the animal studies with the aim of achieving allometric scaling. As from 1950s, BSA-based dosing has been applicable in the case of pediatric oncology. The essence of minimal further studies did not hinder utilization of the BSA-based dosing into drug dose calculation in the context of adults. Currently, BSA-based dosing is proving to the standard through which most agents use to calculate the dose for adults.

Gehan and George (1970) focused in an experiment, which was critical to the development of BSA. This is because of the number of participants (400 individuals) in which the original formula was over-estimation of the real BSA by approximately 15%. The research was also critical in under-estimating the concept of BSA in relation to a number of lower than one percent of the cases or participants. The findings were not crucial in the acceptance of the George and Gehan's BSA formula as the essential medical standard.

In the recent encounter, Mosteller was crucial in transforming the original BSA formula to BSA (m2) = ? ([length (cm) X weight (kg)]/3,600). The new formula in relation to the transformation by Mosteller was a mimic of the original formula thus the simplification of its utilization within the medical sector. Despite the fact that BSA can apply three-dimensional derived formula, the correlation among the formulas remains high (r>0.97). This is an indication of the existence of non-substantive differences in relation to the formulas. There is need to exempt cases of overweight and obese patients. This is because of the tendency the values of BSA to differ significantly in relation to DuBois and Dubois formula as well as other formulas (DuBois & DuBois, 1916).

For this specific case, BSA prediction in accordance with the original formula continues to offer under-estimation of the BSA by approximately 3 and 5 percents in the case of male and female patients respectively in comparison to the new formula under the influence of transformation by Mosteller. Apart from the case of carboplatin, various concerns were on the increase in relation to the application of BSA-based dosing in the case of oncology. It is ideal to note the essence of numerous research studies continuing to illustrate that BSA-based dosing has minimal ability and capacity to generate the desired minimization in relation to inter-individual variation in exposure with reference to adults.

References

DuBois D, DuBois EF. (1916). A formula to estimate the approximate surface area if height and weight were known. Arch Intern Med; 17:863 -- 871.

Boyd E. (1935). The Growth of the Surface Area of the Human Body. Minneapolis:

Gehan EA, George SL. (1970). Estimation of… [END OF PREVIEW]

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Body Surface Area-Based Dosing Flat.  (2013, August 27).  Retrieved August 25, 2019, from https://www.essaytown.com/subjects/paper/body-surface-area-based-dosing-flat/7713758

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