Term Paper: Dosage Levels of Cholestease

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SAMPLE EXCERPT:

[. . .] A p-value of.05 will be used to indicate significance between various groups. The group proving to be the most effective will be the on that shows the greatest degree of lowering cholesterol as measured against the control group. The data will be cross-tabulated between demographic groups to help detect if there is any sample bias within the sample population hat may skew the results.

Delimitations

This research will be exploratory in nature and will serve to help determine within what range the correct may fall in the sample population. The results will only be applicable to the sample population being studied and should not be used to determine proper dosage for any particular patient in the clinical setting. Once the proper dosage range is found according to this study further testing will have to be conducted to determine if that is indeed the clinically correct dosage.

There are many factors that may effect the results of this study and these factors must be considered in the usage of this information for clinical purposes. There are many factors that effect a person's ability to maintain a healthy serum cholesterol level, including diet, exercise levels, stress levels and many individual differences that cannot be determined such as metabolism (5-8). It will not be possible to foresee or eliminate all of the factors that may have an effect on the results of this study. However, statistical controls will be used to help eliminate the severity of any of the effects of these factors. It is expected that these results will be reflective of results that would be found in the general population.

Conclusions

The results of this study are expected to effectively answer the research questions. Even though this study has many potential biases and confounding variables, proper statistical control will be applied and therefore it is expected that the results will be applicable to the general population.

It is expected that the final target dosage will be with the 10 or 15 mg group. This is based on knowledge gained by the rat studies conducted earlier.

This study will be considered preliminary as far as determining dosages as far as clinical applications are concerned. After this study a formal study to determine conclusively that the dosage determined to the be optimal dose is effective in lowering serum cholesterol in human beings. No marketing claims can be made based on this study and will have to wait until further testing is conducted. This study is necessary and further testing cannot be conducted until it is completed. Preliminary results based on studies conducted on laboratory rats look promising as far as expected results of this study are concerned.

This study is only the next step in the development of the final product for marketing to clinicians and usage on the general public. Cholesterease is expected to be a product in high demand and fills a niche in the market that is not currently be addressed. Cholesterease solves many of the problems associated with competitor products and has no competition in Great Britain. The elimination of side effects associated with competitor products is expected to be a key selling point that will put Cholesterease ahead of its competition.

End Notes

Isles, C.G. et al., (1989) Plasma cholesterol, coronary heart disease, and cancer in the Renfrew and Paisley survey. Brit. Med. J. 298 (6678) p. 920-924.,

Manson, J. et al., (1992)The primary prevention of myocardial infarction. N. Eng. J. Med.

326 (21) / p.1406-1416.

Kronmal, R. et al. (1993) Total Serum Cholesterol Levels and Mortality Risk as a function of Age, A report based on the Framingham Data. Arch. Intern. Med 153 p.1065-1073.

Hudson, M.(2003) How Cholesterol Affects the Body. BurnBraeFarms.com. (Online at (http://www.burnbraefarms.com/nutrition/cholesterolnews.pdf) Accessed June 4, 2003.

Parker-Pope, T.(2002) Cholesterol Drug Raises Questions About Side Effects. Wall Street

Journal. February 1, 2002.

Howell, W. et al. (1997) Plasma lipid and lipoprotein responses to dietary fat and cholesterol: a meta-analysis. Am. J. Clin. Nutr. 65 p. 1747-1764.

Otani H, et. al. (1992) Long-term effects of a cholesterol-free diet on serum cholesterol levels in Zen monks. New England Journal of Medicine. P. 326:416.

Clarke, R. et al. (1997) Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies. Brit. Med. Journal 314 p.112-117.

Rozzini, R. et al., (1996) Low serum cholesterol and serotonin metabolism. Risk of depression is higher in elderly patients with lowest cholesterol values. Brittish Medical Journal 312 (7041) p. 1298-1299.

Howell, W. et al. (1997) Plasma lipid and lipoprotein responses to dietary fat and cholesterol: a meta-analysis. Am. J. Clin. Nutr. 65 p.1747-1764.

Bibliography

Clarke, R. et al. (1997) Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies. Brit. Med. J 314 p.112-117.

Howell, W. et al. (1997) Plasma lipid and lipoprotein responses to dietary fat and cholesterol: a meta-analysis. Am. J. Clin. Nutr. 65 p.1747-1764.

Hudson, M. (2003) How Cholesterol Affects the Body. BurnBraeFarms.com. (Online at (http://www.burnbraefarms.com/nutrition/cholesterolnews.pdf) Accessed June 4, 2003.

Kronmal, R. et al. (1993)Total Serum Cholesterol Levels and Mortality Risk as a function of Age, A report based on the Framingham Data. Arch. Intern.Med. 153 p. 1065-1073.

Manson, J. et al., (1992) The primary prevention of myocardial infarction. N. Eng. J. Med. 326 (21) p.1406-1416.

Otani H, et. al. (1992) Long-term effects of a cholesterol-free diet on serum cholesterol levels in Zen monks. N Eng J. Med. 326 p. 416.

Parker-Pope, T. (2002) Cholesterol Drug Raises Questions About Side Effects. Wall Street Journal. February 1, 2002.

Isles, C.G. et al., (1989) Plasma cholesterol, coronary heart disease, and cancer in the Renfrew and Paisley survey. Brit. Med. J. 298 (6678) p. 920-924.,… [END OF PREVIEW]

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