Term Paper: Radiopharmaceutical GA-68 DOTATOC

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¶ … 68Ga]-DOTATOC in Imaging Neuroendocrine Tumors

Non-invasive imaging and monitoring of neuroendocrine tumors has traditionally relied upon conventional scintigraphy and/or dedicated CT (111ln-octreotide scintigraphy). Imaging and monitoring of neuroendocrine tumors through the detection and tracking of tumor-based somatostatin receptors using diagnostic somatostatin analogs is still relatively new, yet current research suggests that it can be far more accurate than traditional methodologies (Hofmann et al., 2001; Buchmann et al., 2007; Gabriel et al., 2007; Poeppel et al., 2011). One study showed that the newer technique achieved a sensitivity of ninety-seven percent, a specificity of ninety-two percent, and an accuracy of ninety-six percent, with only one false positive tumor detection and two false negative results in a data pool of eighty-four patients (Gabriel et al., 2007). Traditional tumor detection methods applied in the same study had significantly higher false negatives and failures to diagnose tumors in many areas of the body, whereas the two false negatives resulting from [68Ga]-DOTATOC somatostatin receptor analysis were both related to tumors in the gastrointestinal tract with liver metasteses (Gabriel et al., 2007). The continued study of various artificial somatostatin analogs as a means of imaging neuroendocrine tumors is called for by these preliminary findings.

More specifically, the study of [68Ga]-DOTATOC as the most effective of these analogs is also warranted by the research ((Hofmann et al., 2001; Buchmann et al., 2007; Gabriel et al., 2007; Poeppel et al., 2011). Much of the current literature finds that [68Ga]-DOTATOC PET applications and other PET applications using other somatostatin analogs are more effective than traditional methods of neuroendocrine tumor detection and monitoring, and the general recommendation of including such testing as a part of best practices can already be made (Hoffmann et al., 2011; Gabriel et al., 2007). Studies comparing the accuracy and efficacy of [68Ga]-DOTATOC in relation to other somatostatin analogs used in similar or otherwise identical PET studies also suggest that [68Ga]-DOTATOC is more effective and accurate than other somatostatin analogs, however these results are not as conclusive and call more fervently for further research in order to establish the true accuracy level of [68Ga]-DOTATOC in relation to other neuroendocrine tumor detection and monitoring methods (Buchmann et al., 2007; Poeppel et al., 2011). Establishing and confirming best practices in this regard will lead to greater efficiency and cost-effectiveness in diagnostic testing and to substantially better patient outcomes through increased accuracy and the earlier detection and treatment of neuroendocrine tumors.

Project Design and Procedures

Potential participants who have recently undergone diagnostic treatment at one of several area hospitals will be contacted by current physician and/or nursing staff to ascertain initial desire to participate, with contact by research… [END OF PREVIEW]

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Radiopharmaceutical GA-68 DOTATOC.  (2012, October 12).  Retrieved December 9, 2019, from https://www.essaytown.com/subjects/paper/radiopharmaceutical-ga-68-dotatoc/1901813

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"Radiopharmaceutical GA-68 DOTATOC."  12 October 2012.  Web.  9 December 2019. <https://www.essaytown.com/subjects/paper/radiopharmaceutical-ga-68-dotatoc/1901813>.

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"Radiopharmaceutical GA-68 DOTATOC."  Essaytown.com.  October 12, 2012.  Accessed December 9, 2019.
https://www.essaytown.com/subjects/paper/radiopharmaceutical-ga-68-dotatoc/1901813.