Essay: Therapeutic Hypothermia Review Annotated Bibliography

Pages: 5 (1429 words)  ·  Bibliography Sources: 10  ·  Level: Master's  ·  Topic: Healthcare  ·  Buy This Paper


[. . .] What was found was that the neurological outcomes for individuals who received pre-hospital cooling as compared to those patients the previous year who did not receive pre-hospital hypothermia. It is reported by Sayre et al. (2010) that in a study involving 12 surviving individuals eight of these receiving pre-hospital hypothermia had initial cardiac rhythms of ventricular fibrillation. Of those eight, seven were discharged with a neurological status that was 'good' (CPC 1 or 2) and one was discharged to a skilled nursing home reporting a "severe neurologic deficit (CPC # or 4)." (Sayre, et al., 2010, p. 5)

Recommendations arising from this study include the following stated Recommendations: (1) "EMS systems should continuously collect detailed, accurate and complete cardiac arrest data including neurologic outcome statistics which enable analysis of new practices and improvements in survival"; (2) "EMS professionals must maintain both skills and knowledge related to advances in resuscitation science, particularly because these patients are not encountered on a regular basis"; (3) "Improving the quality of pre-hospital care is of ultimate importance in the chain-of-survival for victims of sudden cardiac arrest. Implementation of true continuous quality improvement (CQI) is imperative. To be effective, CQI cannot be episodic or target only outliers or poor outcome. Improved survival for SCA victims reflects the quality and dedication to detail of the EMS system caring for these patients." (Sayre, et al., 2010, p.5) A charted analysis of the study reviewed in section of this work in writing is listed in the following table labeled Figure 1 in this study.

Figure 1

Analysis of Findings: Sayre et al. (2010)

There were not any apparent ethical issues to be addressed in this study other than the general consent acquisition that is needed from those participating in the study through rendering of the information concerning their treatment and outcome available to be tabulated and analyzed in the study reported. The study reported by Sayre (2010) is a qualitative and quantitative study in that the literature reviewed in the study was in the form of qualitative research and was descriptive and interpretive in nature. Patient information contained in the case study in this report is quantitative due to the information being analyzed in terms of percentages and patient outcomes. Quantitative research in this study is specifically needed so that the data relating to improved outcomes in patients with cardiac arrest and receiving pre-hospital hypothermia treatment can be best analyzed.

Therapeutic Hypothermia Review

Part Three

The work of Laird (2009) entitled "Induced Hypothermia for Neuroprotection Following Cardiac Arrest: A Review of the Literature" reports that cardiac arrest mortality rates occurring outside the hospital are more than 90% and the individuals surviving such cardiac arrest "neurological injury remains a lasting morbidity." (p.1) Laird (2009) additionally reports that randomized-control trials have proved the use of induced hypothermia in select patient populations effective at reducing mortality and improving neurological outcomes." (p.1) According to this report upon the individual sustaining a cardiac arrest, "depletion of cerebral oxygen stores rapidly ensues. Within 20 seconds, the patient loses consciousness. Within five minutes, glucose and adenosine triphosphate stores are depleted. During the period of cardiac arrest, membrane depolarization, the influx of calcium ions, metabolic acidosis, glutamate release, and the activation of numerous enzymes occurs. Reperfusion injury occurs once cerebral perfusion has been restored, which causes the release of free radicals, calcium shifts, catecholamine release, and amino acid release that leads to mitochondrial damage. Reoxygenation following cardiac arrest causes further neurological damage secondary to delayed necrosis of the tissue as well as apoptosis of the neuronal tissue." (Laird, 2009, p.1)


Background Literature Review Methodology Data Analysis Conclusion


Individuals suffering cardiac arrest are known to have outcomes that are undesirable in regards to neurological function. Literature review supports the need for pre-hospital hypthermia treatment for preserving neurologic function following cardiac arrest. Review of literature and case study of patients admitted with cardiac arrest. Data analysis was conducted in percentage tabulation of data in the study. There was not shown to be an increase in the surivival rates of patients when baseline year was compared to first year of study. It was shown that pre-hospital hypothermia treatment increased percentage of individuals at discharge with good neurologic function. [END OF PREVIEW]

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Therapeutic Hypothermia Review Annotated Bibliography.  (2011, January 10).  Retrieved May 21, 2019, from

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