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Brefeldin A: Miracle and Curse Research Paper

… Upside and Downside of Brefeldin A

Brefeldin A (BFA) is a versatile compound in common use in many cell biological research laboratories around the world and has been very useful in dissecting signal transduction pathways in mammalian and plant cells (Nebenfuhr, Ritzenthaler, & Robinson, 2002). Preparations of BFA are derived from the fungus Penicillium brefeldianum or synthesized chemically (Sigma, n.d.; MycoBank, 2015). In the laboratory, BFA can be used to block protein transport from the endoplasmic reticulum to the Golgi (EMD Millipore, 2015). BFA performs this function specifically and reversibly, without affecting endocytosis or lysosome functions. BFA also has antifungal, antiviral, and macrolide antibiotic activity and is currently under development as a possible chemotherapeutic agent for cancer treatment (ChemSpider, 2015). This report will examine the…. [read more]

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